Associate Professor

Molecular Biology

I am an immunologist whose interests lie at the intersection of immunology,
virology, and cancer biology. My research interests center on B cell biology and how
it is manipulated by Epstein-Barr Virus (EBV).

Publications

Epstein-Barr virus modulates host cell microRNA-194 to promoteIL-10 production and B lymphoma cell survival.
Harris-Arnold A, Arnold CP, Schaffert S. Hatton O, Krams SM, Esquivel CO, Martinez OM.
Am J Transplant. 2015 Nov;15(11):2814-24. doi: 10.1111/ajt.13375. Epub 2015 Jul 3.
PMID: 26147452

The interplay between Epstein-Barr virus and B lymphocytes: implications for infection, immunity, and disease.
Hatton OL, Harris-Arnold A, Schaffert S, Krams SM, Martinez OM.
Immunol Res. 2014 May;58(2-3):268-76. doi: 10.1007/s12026-014-8496-1. Review.
PMID: 24619311 Free PMC Article

Syk-induced phosphatidylinositol-3-kinase activation in Epstein-Barr virus posttransplant lymphoproliferative disorder.
Hatton O, Lambert SL, Phillips LK, Vaysberg M, Natkunam Y, Esquivel CO, Krams SM, Martinez OM.
Am J Transplant. 2013 Apr;13(4):883-90. doi: 10.1111/ajt.12137. Epub 2013 Feb 7.
PMID: 23398911 Free PMC Article

Src kinase and Syk activation initiate P13K signaling by a chimeric latent membrane protein 1 in Epstein-Barr virus (EBV)+ B cell lymphomas.
Hatton O, Lambert SL, Krams SM, Martinez OM.
PLoS One. 2012;7(8):e42610. doi: 10.1371/journal.pone.0042610. Epub 2012 Aug 3.
PMID: 22880054 Free PMC Article

Emerging therapeutic strategies for Epstein-Barr virus+post-transplant lymphoproliferative disorder.
Hatton O, Martinez OM, Esquivel Co.
Pediatr Transplant. 2012 May;16(3):220-9. doi: 10.1111/j.1399-3046.2012.01656.x. Epub 2012 Feb 21. Review
PMID: 22353174 Free PMC Article

Syk activation of phosphatidylinositol 3-kinasa/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein
(XIAP) to promote survival of Epstein-Barr virus+(EBV+) B cell lymphomas.
Hatton O, Phillips LK, Vaysberg M, Hurwich J, Krams SM, Martinez OM.
J Biol Chem. 2011 Oct 28;286(43):37368-78. doi: 10.1074/jbc.M111.255125. Epub 2011 Sep 9.
PMID: 21908615 Free PMC Article

Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos.
Vaysberg M, Hatton O, Lambert SL, Snow AL, Wong B, Krams SM, Martinez OM.
J Biol Chem. 2008 Dec 26;283(52):36573-85. doi: 10.1074/jbc.M802968200. Epub 2008 Nov 5.
PMID: 18986987 Free PME Article

 

 

Regular Classes

MB131 - Introduction to Molecular and Cellular Biology
MB201 - Laboratory in Molecular and Cellular Biology and Genetics
MB301 - Special Topics in Molecular Biology: Immunology
MB350 - Special Topics in Laboratory Research in Molecular Biology
MB497 - Senior Capstone in Molecular Biology

 

Committees & Governance

Dean;s Advisory Committee - 2016/17
Summer Collaborative Research (SCoRe) Faculty Steering Committee - 2016