Abstract
The present study quantitatively explored the dendritic/spine extent of supragranular pyramidal neurons across several cortical areas in two adult males who had undergone a callosotomy several decades prior to death. In all cortical areas, there were numerous atypical, surpragranular pyramidal neurons with elongated “tap root” basilar dendrites. These atypical cells could be associated with an underlying epileptic condition, and/or could represent a compensatory mechanism in response to deafferentation following callosotomy.