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Chemistry & Biochemistry

www.coloradocollege.edu/academics/dept/chemistry/

Professors BOWER, LINDEMAN, MEYER; Associate Professors BRASUEL (chair), GROVER; Assistant Professors DAUGHERTY, DOUNAY, VAGHOO; Visiting Assistant Professor WOWOR

THE MAJORS — REQUIREMENTS:

Students are encouraged to choose a specific sub-discipline and focus in related upper level courses. Upper-level courses in cognate disciplines that fit specific sub-disciplines of chemistry may be substituted as equivalent if approved by the department. In addition every senior must enroll in CH490. Computational approaches, including programming and statistical analysis, are integrated into the majors, but more experience may be useful.

A chemistry major must receive credit for courses equivalent to Chemistry 107, 108; Mathematics 126, 129; Physics 241, 242; Chemistry: 241, 250, 366 or 365, 275, 382. One of these five chemistry courses may be replaced by an upper-level chemistry course or an approved upper-level course in a cognate discipline. Students must take three upper-level courses chosen from: Chemistry 251, 342, 351, 367, 383, 475, one credit of (CH301, 401, 403) and other approved upper level chemistry courses that contain a significant laboratory. The department recommends research for all students but especially those intending to pursue graduate study.

A biochemistry major must receive credit for courses equivalent to Chemistry 107, 108; Mathematics 126, 129; Physics 241, 242; Biology 231; Chemistry: 250, 251, 382, 383 and either 241 or 366 or 365; one credit of (CH301, CH401, or CH403),and two additional credits from the upper-level courses: Chemistry 342, 351, 367, 475, Biology 304, 344, 345, 363, 366, 380 when a significant laboratory component is included. Additional upper-level biochemistry or molecular biology courses when taught with a significant relevant laboratory component may also be approved by the department.

Students interested in graduation with distinction in chemistry or biochemistry should discuss the requirements with a department advisor by spring of their junior year. Distinction involves research and a significant thesis or publishable manuscript. Students interested in receiving American Chemical Society certification should also consult an advisor within the department.

THE MINORS — REQUIREMENTS:

A chemistry minor must receive credit for courses equivalent to Chemistry 107, 108, 250, and three additional credits selected from 251, 241, 275, 382 or other 300- and 400-level chemistry and biochemistry courses in this catalog (with their prerequisites). Investigations in Chemistry can count as one of the upper level courses. A biochemistry minor must receive credit for 382 as one of the three courses taken beyond 250.

Chemistry Courses

100 Studies in Chemistry:

Selected topical areas, such as forensic science, materials science, environmental science, history of chemistry, chemistry and art, or nutritional, medicinal and consumer chemistry taught at the introductory level from a chemical perspective. Intended for (but not typically limited to) non-science majors, these courses will usually include moderate lab or fieldwork and independent or group research projects. Some topics may give Scientific Inquiry and Natural Science Lab credit. 1 or 2 units - Department

1 unit —

104 Topics in Chemistry:

Selected topics in chemistry taught at the introductory level. units.

.5 unit —

107 General Chemistry I

107 emphasizes the basic principles of atomic structure, periodic properties, molecular structure and bonding, chemical reactions, and stoichiometry. Laboratory included. Meets the Critical Perspectives: Scientific Investigation of the Natural World lab or field requirement. Meets the Critical Perspectives: Quantitative Reasoning requirement.

Prerequisite: consent of instructor or 2yrs HS Algebra & 1yr HS Chemistry.

1 unit —

108 General Chemistry II

108 emphasizes kinetics, thermodynamics, equilibrium, and solution chemistry of acid-base and redox reactions. Laboratory included. Meets the Critical Perspectives: Scientific Investigation of the Natural World lab or field requirement. Meets the Critical Perspectives: Quantitative Reasoning requirement.

Prerequisite: Chemistry 107.

1 unit —

113 Art and Alchemy-Investigating the Origins of Chemistry

(Not offered 2013-14).

Prerequisite: First Year Experience Course, Must take Studies in Natural Science 109 for credit.

1 unit

117 General Chemistry I with Environmental Emphasis

(Not offered 2013-14).

1.5 units

148 Physics and Chemistry by Experimentation

(Not offered 2013-14).

Prerequisite: First Year Experience Course.

1 unit

149 Physics and Chemistry by Experimentation

(Not offered 2013-14).

Prerequisite: First Year Experience Course. Must take Physics 148 block 1 for credit.

1 unit

199 Computational Chemistry

An examination of the tools available for studying models of chemical systems. FORTRAN programming, Evolution Algorithms, Neural Networks, Molecular Modeling software, and Computer Graphics will all be introduced. This is a project based course with topics chosen to match the level of individual students' chemistry backgrounds. (Not offered 2013-14).

Prerequisite: Mathematics 128.

.5 unit

201 Investigations in Chemistry:

Independent experimental practice research in areas such as biochemistry, organic chemistry, physical chemistry, inorganic chemistry, catalysis, analytical chemistry and environmental chemistry performed in affiliation with a staff member. A total of three units of Investigations may be taken for credit.

Prerequisite: consent of instructor.

1 unit —

202 Investigations in Chemistry:

Independent experimental practice research in areas such as biochemistry, organic chemistry, physical chemistry, inorganic chemistry, catalysis, analytical chemistry and environmental chemistry performed in affiliation with a staff member. A total of three units of Investigations may be taken for credit. Extended format course.

.5 unit —

210 Environmental Chemistry

A focus on the thermodynamics and kinetics of pollutants in the air, water, and soil, as well as some toxicology. Statistical methods and the analysis of environmental samples using instrumental methods as well as techniques in chemical waste treatment are covered. Meets the Critical Perspectives: Scientific Investigation of the Natural World requirement. (Not offered 2013-14).

Prerequisite: Chemistry 250 or (Chemistry 108 & (Biology 208 or Geology 130 or Geology 140)).

1 unit

241 Introduction to Analytical Chemistry

The methodologies of quantitative and qualitative chemistry applied to analytical and/or bioanalytical problems in aqueous chemistry. Basic techniques of separation, spectroscopy, and electrochemistry are introduced through a study of chemical speciation and the activity of chemicals in solution. Laboratory included. Meets the Critical Perspectives: Scientific Investigation of the Natural World requirement.

Prerequisite: Chemistry 107 and 108 and one 200 level college science course or consent of instructor.

1 unit —

250 Structures of Organic Molecules

Basic concepts necessary for understanding chemical reactions. Nomenclature, structure, physical properties and spectroscopy of simple organic molecules. Fundamentals of thermodynamics and reaction kinetics. Laboratory included. Meets the Critical Perspectives: Scientific Investigation of the Natural World requirement.

Prerequisite: Chemistry 108.

1 unit —

251 Reactions of Organic Molecules

Characteristic reactions of common organic functional groups. Mechanisms, rates and equilibria. The course depends heavily on concepts developed in 250. Laboratory included. Meets the Critical Perspectives: Scientific Investigation of the Natural World requirement.

Prerequisite: Chemistry 250.

1 unit —

275 Foundations of Inorganic

Atomic structure, models and theories of bonding, bond types underlying metals, semiconductors, ionic solids and materials. Lewis acid-base interactions, coordination complexes, associated reaction mechanisms, and other aspects of transition metal chemistry. Atomic-level origins of special material properties such as ferromagnetism and electroluminescence.

Prerequisite: Chemistry 107, 108.

1 unit —

296 Special Topics in Chem:

Selected by the student with the advice of the instructor. Class and laboratory arranged. No more than six of these courses, i.e., 1.5 units, can be counted toward graduation. Only a total of three units of Investigations in Chemistry and Special Topics in Chemistry combined can be counted toward graduation.

Prerequisite: consent of instructor.

.25 unit —

300 Topics in Chemistry or Biochemistry

This course provides opportunity for topical work. No more than three units of Investigations, Topics, and Advanced Topics may be taken for department credit. (Not offered 2013-14).

.5 to 1 unit

301 Investigations in Chemistry:

Independent experimental practice research in areas such as biochemistry, organic chemistry, physical chemistry, inorganic chemistry, catalysis, analytical chemistry and environmental chemistry performed in affiliation with a staff member. A total of three units of Investigations may be taken for credit.

Prerequisite: consent of instructor.

1 unit —

302 Investigations in Chemistry:

Independent experimental practice research in areas such as biochemistry, organic chemistry, physical chemistry, inorganic chemistry, catalysis, analytical chemistry and environmental chemistry performed in affiliation with a staff member. A total of three units of Investigations may be taken for credit. Extended format course.

.5 to 1 unit —

342 Introduction to Instrumental Methods

The principles and theory of modern instrumental analysis taught through topics selected from electrochemistry, spectroscopy and chromatography. The design and analysis of optimized experiments will be illustrated through research-oriented topics that also teach the instrumental methods being emphasized.

Prerequisite: Chemistry 241 or Chemistry 345 & Physics 242 (Chemistry 365, Chemistry 366, or consent of instructor.

1 unit —

345 Bioanalytical Chemistry

Analysis of biomolecules using chemical and biological techniques. Emphasis will be placed on protein and DNA structure, chromatographic and electrophoretic separations and methods of quantitation. Course format includes laboratories, special projects and discussions of current literature and reviews. (Not offered 2013-14).

Prerequisite: Chemistry 382.

1 unit

351 Synthesis of Organic Molecules

Application of structural concepts and functional group reactions to the synthesis of organic compounds. Factors in the design of multistep syntheses such as functional group transformation, elaboration of carbon chains, protecting groups and reaction stereochemistry. Examples from the literature of laboratory syntheses of complex molecules such as steroids, alkaloids and pharmaceuticals will be examined. Laboratory included.

Prerequisite: Chemistry 251.

1 unit —

352 Physical Organic Chemistry

Application of thermodynamics and kinetics to the study of organic reaction mechanisms. Elucidation of mechanisms via the use of molecular orbital theory, isotope effects, substituent effects and linear free-energy relationships, solvent effects, characterization of reactive intermediates, gas-phase chemistry and computations. Laboratory included. (Either 351 or 352 will count as the advanced organic chemistry requirement for the chemistry major, or as an elective for the biochemistry major. The two courses, however, are not the same and both can be applied toward graduation requirements.) (Not offered 2013-14).

Prerequisite: Chemistry 250, 251 & 366.

1 unit

365 Biophysical Chemistry

Thermodynamics, chemical kinetics and dynamics as applied to living systems and biopolymers. Homogeneous and heterogeneous equilibria and chemical potential as a driving force in biological reactions. Measurement and interpretation of rate behavior in biochemical systems. Diffusion, osmotic pressure and sedimentation. Laboratory focusing on biophysical experiments and error analysis included.

Prerequisite: Chemistry 241/345, Mathematics 128, Physics 241 & knowledge computer programming.

1 unit —

366 Physical Chemistry I

Thermodynamics and chemical kinetics, especially as applied to practical aspects of technology and living systems. Equilibrium relationships in various homogeneous and heterogeneous states. Laboratory included.

Prerequisite: Chemistry 107 and Chemistry 108, Physics 241, Mathematics 128.

1 unit —

367 Physical Chemistry II

Structures and dynamics of physical systems, from a molecular point of view. The central aspects of quantum behavior, elementary statistical mechanics and theories of reaction rates. Emphasis on analyzing spectroscopic data, and on computational approaches to quantum-mechanical systems. Laboratory included. Prerequisite: CH 366, CH 365 or COI

Prerequisite: Chemistry 366.

1 unit —

382 Biochemistry I

An introduction to modern biochemistry using fundamental chemical principles in the study of complex natural systems. Topics covered are proteins, carbohydrates, lipids, bioenergetics, enzymology, and metabolism with an emphasis on interrelationships between metabolic pathways and regulation. Laboratory included. Limited to 16 students.

Prerequisite: Chemistry 251.

1 unit —

383 Biochemistry II

Study of nucleic acids organization and structure, DNA replication and transcription, RNA processing and protein biosynthesis, and the regulation of gene expression. A special emphasis on the use of the original literature. Laboratory included. Limited to 16 students.

Prerequisite: Chemistry 382.

1 unit —

395 Chemistry Tutoring Practicum

This course is designed for students who wish to tutor general and organic chemistry. It includes methods for improved listening skills, assessing student content knowledge, teaching problem solving, and conceptual analysis. Methods used in the course include peer tutoring, experiential exercises, journal writing, and supervised tutoring. The class is recommended for those students desiring chemistry department payment for tutoring.

Prerequisite: Chemistry 250 or consent of instructor.

.25 to 1 unit —

396 Special Topics in Chemistry:

Selected by the student with the advice of the instructor. Class and laboratory arranged. No more than six of these courses, i.e., 1.5 units, can be counted toward graduation. Only a total of three units of Investigations in Chemistry and Special Topics in Chemistry combined can be counted toward graduation.

Prerequisite: consent of instructor.

.25 unit —

400 Advanced Topics in Chemistry

This course provides opportunity for advanced topical work. Topics will vary from year to year. No more than three units of Investigations, Topics and Advanced Topics may be taken for department credit.

1 unit —

401 Investigations in Chemistry:

Independent experimental practice research in areas such as biochemistry, organic chemistry, physical chemistry, inorganic chemistry, catalysis, analytical chemistry and environmental chemistry performed in affiliation with a staff member. A total of three units of Investigations may be taken for credit.

Prerequisite: consent of instructor.

1 unit —

402 Investigations in Chemistry:

Independent experimental practice research in areas such as biochemistry, organic chemistry, physical chemistry, inorganic chemistry, catalysis, analytical chemistry and environmental chemistry performed in affiliation with a staff member. A total of three units of Investigations may be taken for credit. Extended format course.

.5 to 1 unit —

403 Research Problems in Biochemistry

An independent research project based on laboratory investigation in biochemistry. The student should choose the original research topic with advice from member(s) of the department prior to registration in the class.

Prerequisite: Chemistry 382 & consent of instructor.

1 unit —

452 Topics in Advanced Organic Chemistry

One of the following topics will be investigated in both the literature and the laboratory: (1) Nuclear Magnetic Resonance Spectroscopy; (2) Fourier Transform Infrared Spectroscopy; (3) Mass Spectrometry/Gas Chromatography; (4) Spectroscopic Methods in Structure Determination. Extended-format course. (Not offered 2013-14).

Prerequisite: consent of instructor & Chemistry 367 & 351.

.5 unit

467 Spectroscopy and Quantum Mechanics

The detailed interpretation of molecular structure and spectra. Quantum theory and chemical statistics are applied to the interactions of electromagnetic radiation with molecules. Laboratory included. (Not offered 2013-14).

Prerequisite: consent of instructor or Chemistry 367 & Mathematics 203.

1 unit

475 Inorganic Chemistry I

The periodic table and trends within it, focusing on the following substances: metals, ionic compounds, molecular compounds, organometallic compounds and coordination complexes. Models of chemical bonding will be compared for each class of substance. Special topics such as the boron hydrides, metal clusters, inorganic polymers and nonexistent compounds. Laboratory included. (Not offered 2013-14).

Prerequisite: consent of instructor or Chemistry 367.

1 unit

476 Topics in Transition Metal Chemistry

One of the following topics will be investigated in both the literature and the laboratory: (1) Electronic Spectra; (2) Magnetic Properties; (3) Biochemical Aspects; (4) Metal Cluster Compounds; (5) Ligand Substitution Reactions; (6) Electron Transfer Reactions. Extended-format course. (Not offered 2013-14).

Prerequisite: Chemistry 475.

.5 to 1 unit

480 Advanced Metabolic

Investigation of the regulation and energy transductions in protein metabolism and cholesterol synthesis, with emphasis on integration of material with carbohydrate and lipid metabolism. Special emphasis will be on presentation of scientific literature related to inborn errors of metabolism. Laboratory included. (Not offered 2013-14).

1 unit

490 Senior Seminar

An adjunct course spread out over the whole year in which guest lecturers and juniors and seniors present their independent research (either literature or laboratory) to the department in both oral an poster disciplinary presentation formats.. One semester required in the senior year for both chemistry and biochemistry majors.

Prerequisite: Required for Chemistry Majors.

.5 unit —

495 Special Topics in Chem:

Selected by the student with the advice of the instructor. Class and laboratory arranged. No more than six of these courses, i.e., 1.5 units, can be counted toward graduation. Only a total of three units of Investigations in Chemistry and Special Topics in Chemistry combined can be counted toward graduation.

Prerequisite: consent of instructor.

.25 to 1 unit —

499 Senior Thesis

A thesis topic to be chosen by student with advice from a member (or members) of the department. Upon presentation of thesis proposal by the student, department faculty will authorize or deny registration in 499.

Prerequisite: consent of department.

.5 to 1 unit —